Neuroleptic Malignant Syndrome (NMS) — rare but potentially fatal complication of antipsychotic medicines — medical emergency
Signs and Symptoms
- High temp, altered consciousness, confusion, muscle stiffness
- May have fluctuating pulse and BP, fast RR, raised CK
Do
- Stop all antipsychotic medicines straight away
- Maintain fluids (hydration)
- Send to hospital urgently
|
Extra-pyramidal side effects (EPSE)
Signs and Symptoms
- Muscular shaking (tremors)
- Dystonia (muscular spasms) including spasm of larynx
- Parkinsonism (muscular stiffness, rigidity)
- Akathisia (restlessness, agitation)
- Dyskinesia (involuntary twisting/squirming, mouth/tongue movements)
- Oculogyric crisis (eyes up, hard to look down, bending back of head, grimace)
- Hypersalivation (drooling, dribbling)
Do
- Give benzatropine IM — adult 1–2mg, single dose
- Symptoms should resolve in 15 minutes
|