Other medicines doses table [On line]- Ed2022

Benzatropine

This table must be used with protocols from CARPA STM (8th ed) or WBM (7th ed) – it does not provide all the information needed for appropriate treatment.

Notes:

  • Pregnancy: B2 – safe to use
  • Breastfeed: Appears safe
  • Doses (mL) rounded up to nearest 0.2mL unless this is more than 10% above recommended dose

† = other strengths and forms available. Doses in brackets (mL, tab) only apply to forms and strengths listed.

For more information and details on giving medicine see AMH, Therapeutic Guidelines, Australian Injectable Drugs Handbook, Medicines Book. 

 

Dexamethasone

This table must be used with protocols from CARPA STM (8th ed) or WBM (7th ed) – it does not provide all the information needed for appropriate treatment.

Notes:

  • Pregnancy: A – safe, but use lowest dose for shortest time
  • Breastfeed: Use alternative if available
  • Give IV over 1–3 minutes
  • Give IM if no IV access
  • Doses (mL) rounded up to nearest 0.2mL unless this is more than 10% above recommended dose

† = other strengths and forms available. Doses in brackets (mL, tab) only apply to forms and strengths listed.

For more information and details on giving medicine see AMH, Therapeutic Guidelines, Australian Injectable Drugs Handbook, Medicines Book.

 

Hydrocortisone

This table must be used with protocols from CARPA STM (8th ed) or WBM (7th ed) – it does not provide all the information needed for appropriate treatment. 

Notes:

  • Pregnancy: A – safe, but use lowest dose for shortest time
  • Breastfeed: Safe to use, avoid high doses
  • Give IV over 1 minute
  • Give IM if no IV access
  • Doses (mL) rounded up to nearest 0.2mL unless this is more than 10% above recommended dose

For more information and details on giving medicine see AMH, Therapeutic Guidelines, Australian Injectable Drugs Handbook, Medicines Book.

 

Ibuprofen

This table must be used with protocols from CARPA STM (8th ed) or WBM (7th ed) – it does not provide all the information needed for appropriate treatment.

Notes:

  • Pregnancy: C – avoid
  • Breastfeed: Safe to use
  • Doses (mL) rounded up to nearest 0.2mL unless this is more than 10% above recommended dose

† = other strengths and forms available. Doses in brackets (mL, tab) only apply to forms and strengths listed.

For more information and details on giving medicine see AMH, Therapeutic Guidelines, Australian Injectable Drugs Handbook, Medicines Book.

 

Levetiracetam

This table must be used with protocols from CARPA STM (8th ed) or WBM (7th ed) – it does not provide all the information needed for appropriate treatment.

Notes:

  • Pregnancy: B3 – get advice
  • Breastfeed: Caution
  • # Mix measured dose with 100mL normal saline or glucose 5%  
  • Give by IV infusion
    • over 15 minutes for head injury
    • over 5 minutes for fits
  • Doses (mL) rounded up to nearest 0.2mL unless this is more than 10% above recommended dose

For more information and details on giving medicine see AMH, Therapeutic Guidelines, Australian Injectable Drugs Handbook, Medicines Book.

Naloxone

This table must be used with protocols from CARPA STM (8th ed) or WBM (7th ed) – it does not provide all the information needed for appropriate treatment.

Notes:

  • Pregnancy: B1medical consult in opioid-dependent women
  • Breastfeed: May be used
  • # Mix with normal saline to give 0.1mg/mL — 1mL with 3mL, 5mL with 15mL

  • Doses (mL) rounded up to nearest 0.2mL unless this is more than 10% above recommended dose

For more information and details on giving medicine see AMH, Therapeutic Guidelines, Australian Injectable Drugs Handbook, Medicines Book.  

 

Ondansetron

This table must be used with protocols from CARPA STM (8th ed) or WBM (7th ed) – it does not provide all the information needed for appropriate treatment.

Notes:

  • Pregnancy: B1  – safe to use after first trimester if all other options are not suitable
  • Breastfeed: Caution
  • Best antiemetic when sedation not wanted
  • Always do medical consult for children

† = other forms available. Doses listed only apply to this form.

For more information and details on giving medicine see AMH, Therapeutic GuidelinesMedicines Book.

 

Paracetamol

This table must be used with protocols from CARPA STM (8th ed) or WBM (7th ed) – it does not provide all the information needed for appropriate treatment.

Notes:

  • Pregnancy: A  – safe to use
  • Breastfeed: Safe to use
  • If child dose for weight is more than dose for age — use dose for age
  • Doses (mL) rounded up to nearest 0.2mL unless this is more than 10% above recommended dose

† = other strengths and forms available. Doses in brackets (mL, tab) only apply to forms and strengths listed.

For more information and details on giving medicine see AMH, Therapeutic Guidelines, Medicines Book.

 

Prednisolone

This table must be used with protocols from CARPA STM (8th ed) or WBM (7th ed) – it does not provide all the information needed for appropriate treatment.

Notes:

  • Pregnancy: A  – safe, but use lowest dose for shortest time
  • Breastfeed: Safe to use
  • Take after breastfeed and wait 4 hours before next feed
  • Doses (mL) rounded up to nearest 0.2mL unless this is more than 10% above recommended dose

For more information and details on giving medicine see AMH, Therapeutic Guidelines, Medicines Book.  

 

Promethazine

This table must be used with protocols from CARPA STM (8th ed) or WBM (7th ed) – it does not provide all the information needed for appropriate treatment.

Notes:

  • Pregnancy: C – safe to use
  • Breastfeed: Appears safe
  • Best antiemetic if sedation needed
  • Always do medical consult for children
  • Doses (mL) rounded up to nearest 0.2mL unless this is more than 10% above recommended dose

† = other strengths and forms available. Doses in brackets (mL, tab) only apply to forms and strengths listed.

For more information and details on giving medicine see AMH, Therapeutic Guidelines, Australian Injectable Drugs Handbook, Medicines Book.  

Tranexamic acid

This table must be used with protocols from CARPA STM (8th ed) or WBM (7th ed) – it does not provide all the information needed for appropriate treatment.

Notes:

  • Pregnancy: B1  – safe after first trimester
  • Breastfeed: Appears safe
  • Doses (mL) rounded up to nearest 0.2mL unless this is more than 10% above recommended dose

Control bleeding

  • Loading dose
    • For Adults — dilute 1g in 100mL of normal saline or 5% dextrose and infuse over 10 minutes
    • For children — inject undiluted over 10 minutes. Dilute with normal saline if necessary
  • Maintenance dose
    • For Adults — dilute 1g in 1,000mL of normal saline or 5% glucose and infuse over 8 hours
    • For children — dilute 500mg in 500mL of normal saline or 5% glucose to give 1mg/mL and infuse at 2mL/kg/hour over 8 hours (maximum dose 125mg per hour)

Control bleeding in postpartum haemorrhage

  • Inject undiluted over 10 minutes. Dilute with normal saline if necessary

For more information and details on giving medicine see AMH, Therapeutic Guidelines, Australian Injectable Drugs Handbook, Medicines Book.  

Valproate

This table must be used with protocols from CARPA STM (8th ed) or WBM (7th ed) – it does not provide all the information needed for appropriate treatment.

Notes:

  • Pregnancy: D – avoid if possible
  • Breastfeed: Appears safe
  • Doses (mL) rounded up to nearest 0.2mL unless this is more than 10% above recommended dose

IV or intraosseus – Single dose

  • # Inject: Mix with normal saline to give 50mg/mL or less — 400mg with 8mL. Inject over 15 minutes

Infusion dose per hour

  • # Infuse: Mix with 100mL normal saline + 5% glucose to give 4mg/mL

† = other strengths and forms available. Doses in brackets (mL, tab) only apply to forms and strengths listed.

For more information and details on giving medicine see AMH, Therapeutic Guidelines, Australian Injectable Drugs Handbook, Medicines Book.

Use in pregnancy and breastfeeding

For more information on using medicines when a woman is pregnant or breastfeeding, contact your closest Pregnancy Drug Information Centre.

Australian categories for use of medicines in pregnancy

'Harm’ means birth defects or other direct or indirect harm to fetus. For more detail see AMH or Therapeutic Guidelines.

Category A: Have been taken by a large number of pregnant women and women of childbearing age without any known harm
Category B1: Have been taken by a limited number of pregnant women and women of childbearing age without any known harm. Animal studies have not shown harm
Category B2: Women as for B1. Animal studies are poor quality or lacking, but no evidence of harm in available data
Category B3: Women as for B1. Animal studies shown some evidence of harm, but not clear if this is significant for humans
Category C: Have caused or are suspected of causing harm but not malformations. Effects may be non–permanent
Category D: Have caused or are suspected of causing permanent harm
Category X: Have such a high risk of causing permanent harm that they should not be used in women who are or could be pregnant

Notes:

  • The categories of medicine are not hierarchical, eg the allocation of B category does not imply greater safety than C category
  • Category D medicines are not always contraindicated for use in pregnant women. The risks and benefits need to be discussed